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  • Ingredients:

Scientific Evidence for Key Ingredients (Neuropathy)

The studies below suggest these ingredients may help support nerve health or neuropathic discomfort (e.g., diabetic peripheral neuropathy) via antioxidant action, nerve fiber support, or analgesic mechanisms. Individual results may vary. This product is not intended to diagnose, treat, cure, or prevent any disease.

Alpha-Lipoic Acid (ALA)

  • IV ALA improved neuropathic symptoms in short-term RCT (ALADIN). PubMed (1995)
  • Extension/transition study (IV→oral) reported benefit on deficits; symptom effects mixed. PubMed (1999)
  • Recent clinical overview/meta summaries on ALA in DPN. PubMed (2022)

Benfotiamine (Vitamin B1)

  • Pilot randomized trial (3 semanas) mostrou redução de sintomas vs. placebo. PubMed (2005)
  • BENDIP study: benefício como adjuvante em DPN; pede confirmação de longo prazo. PubMed (2008)
  • BOND RCT (12 meses) avaliou desfechos morfo-funcionais e clínicos. PubMed (2022)

Methylcobalamin (Vitamin B12)

  • Double-blind RCT relatou melhora de sintomas vs. placebo. PubMed (1992)
  • 12-month RCT: 1 mg/d oral melhorou dor e neurofisiologia. PubMed (2021)
  • Meta-analysis: evidência mais consistente em combinações; isolado ainda incerto. PubMed (2020)

Acetyl-L-Carnitine (ALC)

  • Cochrane review sobre ALC em DPN com resultados dependentes da dose e duração. PubMed (2019)
  • Review clínico (inclui DPN & CIPN). PMC (2019)
  • Resumo clínico anterior sugerindo benefício potencial. PubMed (2008)

Omega-3 (EPA/DHA)

  • RCT (6 meses) mostrou melhora em corneal nerve fiber length em diabetes tipo 1. PubMed (2021)
  • Reviews recentes sintetizam achados positivos em DPN. PubMed (2025)

Gamma-Linolenic Acid (GLA) – Evening Primrose Oil

  • RCT de 12 meses mostrou melhora clínica em múltiplos parâmetros vs. placebo. PubMed (1993)
  • Overview/PMC sobre GLA/EPO em neuropatia diabética. PMC (2018)

Capsaicin (Topical 8% Patch)

  • Randomized trial: eficácia em dor neuropática diabética (12 semanas). PubMed (2017)
  • Review: não inferior a pregabalin otimizado em PNP não diabética; evidência mista em HIV-AN. PubMed (2016)
  • Dados prospectivos: resposta sustentada até 24 semanas em PDPN. PubMed (2021)

Nota: capsaicina 8% é tópico/dispensado em saúde — incluído aqui por relevância clínica em dor neuropática.

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Updated: Oct 7, 2025 • Links: PubMed/PMC (open in new tab)

References:

Anhê, F. F., Zlitni, S., Zhang, S.-Y., Choi, B. S.-Y., Chen, C. Y., Foley, K. P., Barra, N. G., Surette, M. G., Biertho, L., Richard, D., Tchernof, A., Lam, T. K. T., Marette, A., & Schertzer, J. (2023). Human gut microbiota after bariatric surgery alters intestinal morphology and glucose absorption in mice independently of obesity. Gut, 72(3), 460–472

‌Lomax AR, Calder PC. Probiotics, immune function, infection and inflammation: a review of the evidence from studies conducted in humans. Curr Pharm Des. 2009;15(13):1428-518. doi: 10.2174/138161209788168155. PMID: 19442167.

Forslund, K., Hildebrand, F., Nielsen, T. et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature 528, 262–266 (2015). https://doi.org/10.1038/nature15766

Qin, J., Li, Y., Cai, Z. et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55–60 (2012). https://doi.org/10.1038/nature11450

Zhao, L., et al. (2018). Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science, 359(6380), 1151-1156.

Tilg, H., & Kaser, A. (2011). Gut microbiome, obesity, and metabolic dysfunction. Journal of Clinical Investigation, 121(6), 2126-2132.

This product is not intended to diagnose, treat, cure or prevent any disease.

The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional.

You should not use the information on this site for diagnosis or treatment of any health problem or as a substitute for medication or other treatment prescribed by your physician or health care provider.

You should consult with a physician or healthcare professional before starting any diet, exercise or supplementation program, before taking any medication or food supplement, or if you have or suspect you might have a health problem.

The information we provide is not intended to replace consultation with a qualified medical professional. We encourage you to inform your doctor about any changes you make to your lifestyle and discuss them with him or her. For questions or concerns about any medical conditions you may have, please contact your doctor. The content of the website and the product for sale are based on the author’s opinion and are provided “AS IS” and “AS AVAILABLE”. You should conduct your own research and verify the information with other sources when researching health issues and always review the information carefully with your healthcare professional before using any of the protocols presented on this website and/or the product sold here. Testimonials, case studies, and examples found on this page are results submitted to us by FloraSlim users and may not reflect the typical buyer’s experience, may not apply to an average person, and are not intended to represent or guarantee that any person will achieve the same or similar results. Some names and personally identifying information on this site have been changed to protect individuals’ privacy.

The statements on this website have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information provided by this website or this company is not a substitute for a face-to-face consultation with your physician and should not be construed as individual medical advice. The testimonials on this website are individual cases and do not guarantee that you will get the same results. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. You are encouraged to confirm any information obtained from or through this website with other sources and review all information regarding any medical condition or treatment with your physician. NEVER DISREGARD PROFESSIONAL MEDICAL ADVICE OR DELAY SEEKING MEDICAL TREATMENT BECAUSE OF SOMETHING YOU HAVE READ ON OR ACCESSED THROUGH THIS WEBSITE.